This is a really hard one for me @Series5Ranger. While I’ve seen plenty of anime that probably didn’t get enough attention as they deserved, can’t specifically define one, since I try my best not to go by other people’s reviews.
Well, after sleeping on it for a few hours, one did come to mind (thanks to one of your posts Series5)
Alice and Zoroku
From the just absolutely incredible OP through the final episode, it grabs you and takes you on an emotional roller coaster. You get sentimental over all the main characters, and none of them are just thrown to the side after their introduction. The art is quite beautiful too.